Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.

In this Letter, we present the design and performance of the frequency-dependent squeezed vacuum source that will be used for the broadband quantum noise reduction of the Advanced Virgo Plus gravitational-wave detector in the upcoming observation run. The frequency-dependent squeezed field is generated by a phase rotation of a frequency-independent squeezed state through a 285 m long, high-finesse, near-detuned optical resonator. With about 8.5 dB of generated squeezing, up to 5.6 dB of quantum noise suppression has been measured at high frequency while close to the filter cavity resonance frequency, the intracavity losses limit this value to about 2 dB. Frequency-dependent squeezing is produced with a rotation frequency stability of about 6 Hz rms, which is maintained over the long term. The achieved results fulfill the frequency dependent squeezed vacuum source requirements for Advanced Virgo Plus. With the current squeezing source, considering also the estimated squeezing degradation induced by the interferometer, we expect a reduction of the quantum shot noise and radiation pressure noise of up to 4.5 dB and 2 dB, respectively.

SAFETY AND EFFICACY OF THYMIC PEPTIDES IN THE TREATMENT OF HOSPITALIZED COVID-19 PATIENTS IN HONDURAS.

Coronavirus disease 2019 (Covid-19) active cases continue to demand the development of safe and effective treatments. This is the first clinical trial to evaluate the safety and efficacy of oral thymic peptides. ; We conducted a nonrandomized phase 2 trial with a historic control group to evaluate the safety and efficacy of a daily 250-mg oral dose of thymic peptides in the treatment of hospitalized Covid-19 patients. Comparisons based on standard care from registry data were performed after propensity score matching. The primary outcomes were survival, time to recovery, and number of participants with treatment-related adverse events or side effects by day 20. ; A total of 44 patients were analyzed in this study: 22 in the thymic peptide group and 22 in the standard care group. There were no deaths in the intervention group compared to 24% mortality in standard care by day 20 (log-rank P=0.02). Kaplan-Meier analysis showed a significantly shorter time to recovery by day 20 in the thymic peptide group than in the standard care group (median, 6 days vs. 12 days; hazard ratio for recovery, 2.75 [95% confidence interval, 1.34 to 5.62]; log-rank P=0.002). No side effects or adverse events were reported. ; In patients hospitalized with Covid-19, the use of thymic peptides resulted in no side effects, adverse events, or deaths by day 20. Compared with the registry data, a significantly shorter time to recovery and mortality reduction were measured.

Child Maltreatment and Substance Use: A Behavior Genetic Analysis.

Child maltreatment is a pervasive social problem often perpetuated by family members and is related to a wide array of negative life outcomes. Although substance use is an outcome commonly associated with experiences of child maltreatment, not all individuals who experience maltreatment struggle with such issues. Many individuals can positively adapt to experiences of maltreatment based on levels of resilience and susceptibility. Research suggests that genetic differences may partly explain why negative outcomes develop for some, but not for others. Few studies have examined the extent to which genetic and environmental factors influence the longitudinal association between child maltreatment and varying forms of substance use, leaving a fundamental gap in our current understanding of this association. The current study aims to address this gap by analyzing a sample of twins from the National Longitudinal Study of Adolescent to Adult Health (Add Health). Findings from a series of univariate and bivariate biometric models reveal that the longitudinal associations between maltreatment, cigarette use, and marijuana use are accounted for by additive genetic and nonshared environmental factors. Moreover, the magnitude of the contribution varies across unique subgroups of cigarette and marijuana use. Directions for future research and theoretical implications are discussed.

Mental Health and Victimization: Does Risky Lifestyle Matter?

Research shows that individuals with mental health problems are at an increased risk of victimization compared with individuals without such problems, and certain mental health problems are linked with particular types of victimization. Although most research has not used theory to guide why these differential risks exist, researchers have begun to theorize the reasons why individuals with mental health problems experience victimization. In line with these recent inquiries, the present study uses a Lifestyle/Routine Activities perspective to examine the victimization of people with mental health problems. Further, different types of mental health problems are explored for their potential links to victimization. Risky lifestyle factors are also explored for their potential mediating role in the link between mental health and victimization. A path analysis is conducted with data from the National Longitudinal Study of Adolescent to Adult Health (Add Health). Results suggest that different mental health problems have differing links to victimization types, and lifestyle factors mediate the link for some forms of victimization. The findings imply that certain lifestyle factors explain victimization risk among people with mental health problems, but these individuals may also have unique risk factors related to mental health. Policy implications and directions for future research are discussed.

Identifying Poly-Victimization Among Prisoners: An Application of Latent Class Analysis.

Research suggests that people in prison may be especially vulnerable to victimization and may be more likely to report exposure to multiple types, known as poly-victimization. However, the literature surrounding patterns of victimization among prisoners is limited. Before we can fully understand the variation in victimization experiences among prisoners, a necessary first step is to identify victim profiles within prisons. The current study utilizes data from the 2004 Survey of Inmates in State and Federal Correctional Facilities and employs latent class analysis to identify unique victim profiles among prisoners to understand the variation in victimization experiences, with a focus on identifying those exposed to poly-victimization. The findings of this study indicate (a) that there are four distinct victim profiles-poly-victimization (2%), physical victimization in adulthood (31%), physical victimization in childhood (17%), and low/no victimization (49%); (b) that some prisoners experience poly-victimization, although this consists of a small proportion of prisoners; and (c) that there are clear demographic differences between the latent classes, with some of the largest differences among those in the poly-victimization profile. The findings of the current study are important because they add more depth to the knowledge regarding poly-victimization among prisoners, a topic that has received little attention from researchers. The current study suggests that correctional policy may need to be tailored in a way that recognizes the different needs of prisoners who have been exposed to different forms of victimization.

Does College Matter? Exploring College-Level Factors Related to Victimization Risk for U.S. and Canadian College Students.

Research shows that U.S. college students are at risk for a variety of victimization types. College students in Canada also experience similar types of victimization compared to U.S students, yet recent research shows that Canadian students are at a greater risk than U.S. college students of being victimized. Little is known, however, as to whether college-level factors influence victimization risk and how these risks may be different for U.S. and Canadian college students. Using the American College Health Association's National College Health Assessment data (ACHA-NCHA II), the current study builds upon past research by exploring the role of both individual and school characteristics and whether they are similarly related to risk of victimization in the two populations. The findings show that Canadian students are at higher risk for victimization and that some school-level factors play a role in predicting this risk for all students, with some variation in ones that matter for each country.

Accurate laser frequency locking to optical frequency combs under low-signal-to-noise-ratio conditions.

We demonstrate a method for accurately locking the frequency of a continuous-wave laser to an optical frequency comb under conditions where the signal-to-noise ratio is low, too low to accommodate other methods. Our method is typically orders of magnitude more accurate than conventional wavemeters and can considerably extend the usable wavelength range of a given optical frequency comb. We illustrate our method by applying it to the frequency control of a dipole lattice trap for an optical lattice clock, a representative case where our method provides significantly better accuracy than other methods.

Violent Victimization: The Role of Social Support and Risky Lifestyle.

Although engagement in risky lifestyle and routine activities play a major role in increasing the risk of violent victimization, less is known about the factors that precede engagement in risky lifestyles. The quality of interpersonal relationships is shown to be an important factor that influences one's life. Therefore, the lack of social support may be a potential factor that shapes why individuals get involved in risky lifestyles and routine activities. There is evidence that a lack of social support is linked to victimization and a lack of social support is also linked to engagement in risky lifestyle. What is not understood, however, is how these variables are linked with one another. To address this gap, risky lifestyle factors are explored for their potential mediating role in the link between social support and violent victimization. A path analysis is conducted with data from the National Longitudinal Study of Adolescent to Adult Health (Add Health). The final sample size is 14,322 and the average age of respondents is 16 years old. Results suggest that social support from different sources do not have the same effects on violent victimization, and only certain lifestyle factors mediate the link to violent victimization. The findings imply that a lack of social support not only has direct effects on violent victimization, but also leads individuals to engage in risky lifestyles that also increase the risk of victimization. Policy implications and directions for future research are discussed.

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice.

BACKGROUND AND AIMS: Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. In this study, we evaluated the role of vitamin C and E on non HDL lipoproteins as well as HDL function and remodeling, along with their effects on inflammation/oxidation biomarkers and atherosclerosis in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. METHODS AND RESULTS: Mice were pre-treated for 5 weeks before and during atherogenic diet feeding with vitamin C and E added to water and diet, respectively. Compared to a control group, combined vitamin C and E administration reduced serum total cholesterol and triglyceride levels by decreasing apo B-48-containing lipoproteins, remodeled HDL particles by reducing phospholipid as well as increasing PON1 and apo D content, and diminished PLTP activity and levels. Vitamin supplementation improved HDL antioxidant function and lowered serum TNF-α levels. Vitamin C and E combination attenuated atherogenesis and increased lifespan in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. CONCLUSIONS: Vitamin C and E administration showed significant lipid metabolism regulating effects, including HDL remodeling and decreased levels of apoB-containing lipoproteins, in mice. In addition, this vitamin supplementation generated a cardioprotective effect in a murine model of severe and lethal atherosclerotic ischemic heart disease.

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice

BACKGROUND AND AIMS: Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. In this study, we evaluated the role of vitamin C and E on non HDL lipoproteins as well as HDL function and remodeling, along with their effects on inflammation/ oxidation biomarkers and atherosclerosis in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. METHODS AND RESULTS: Mice were pre-treated for 5 weeks before and during atherogenic diet feeding with vitamin C and E added to water and diet, respectively. Compared to a control group, combined vitamin C and E administration reduced serum total cholesterol and triglyceride levels by decreasing apo B-48-containing lipoproteins, remodeled HDL particles by reducing phospholipid as well as increasing PON1 and apo D content, and diminished PLTP activity and levels. Vitamin supplementation improved HDL antioxidant function and lowered serum TNF-α levels. Vitamin C and E combination attenuated atherogenesis and increased lifespan in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. CONCLUSIONS: Vitamin C and E administration showed significant lipid metabolism regulating effects, including HDL remodeling and decreased levels of apoB-containing lipoproteins, in mice. In addition, this vitamin supplementation generated a cardioprotective effect in a murine model of severe and lethal atherosclerotic ischemic heart disease.

Effect of Propionibacterium acnes (PA) injection on intervertebral disc degeneration in a rat model: Does it mimic modic changes?

INTRODUCTION: Multiple reports of bacterial isolates in human disc tissue have suggested a role of low-grade infection on intervertebral disc degeneration and modic changes (MC) generation. Animal models have been extensively used to study IDD; however, until recently, no consideration had been given to eventual infectious processes. To reproduce the phenomena by inoculating an infecting agent would support the infectious hypothesis. Therefore, we studied the effect of Propionibacterium acnes (PA) inoculation on rat-tails and determined whether it would produce MCs on the adjacent endplates. HYPOTHESIS: Disc infection with PA would accelerate IDD compared with the standard model and would also lead to MCs on the adjacent endplates. METHODS: Twelve Sprague-Dawley rats were randomized to receive a needle puncture in a caudal tail disc with either saline (control) or an inoculum of 5×107 CFU of strain 1a PA. Twelve weeks later, the rats were euthanized and the tails were analyzed. The main assessment criteria were obtained from the post-mortem MRI: T2 values of punctured discs and adjacent endplates, as well as disc volumes. A histological grading score for IDD was also used, measuring the morphology and cellularity of the nucleus and annulus, as well as endplate disruption. RESULTS: The median T2 value and disc volume were smaller in PA-punctured discs [T2 value: 30ms (23-44) vs. 61ms (38-132), respectively, P=0.01; 0.01mm3 (0.01-0.05) vs. 0.5mm3 (0.01-5.35), respectively; P=0.049]. There was no change in the adjacent endplates. There was no significant difference in histological grading between the test and control [13 (10-14) vs. 10.5 (6-13); P=0.05]. DISCUSSION: Inoculation of caudal discs with PA generated increased degeneration; however, no MCs were observed on the adjacent endplates. A better understanding of low-grade disc infections is still needed. LEVEL OF EVIDENCE: V (animal study).

Protective behavioural strategies while drinking: do they protect against sexual victimisation and is this protection gendered?

INTRODUCTION AND AIMS: Although alcohol use has been linked to sexual victimisation among college students , the specific ways in which college students may be able to avoid the negative consequences of excessive drinking as they relate to sexual victimisation have not been fully explored. This study examines whether using protective behavioural strategies attenuates the risk of sexual victimisation for both male and female college students and whether this relationship is moderated by alcohol use. DESIGN AND METHOD: Data were obtained from the Fall 2012 National College Health Assessment Survey. This survey is conducted on college campuses across the USA and institutions that self-selected to participate in the survey. The sample used in the study includes 19 881 students (male and female) across 51 schools. RESULTS: Findings indicate that although women are more likely to use protective behavioural strategies, these strategies work to reduce the likelihood of experiencing sexual victimisation for both sexes among those who are high-frequency drinkers. DISCUSSION AND CONCLUSIONS: This study suggests that the frequency of alcohol use is important when considering the risk of sexual victimisation among college students, and protective behavioural strategies can help reduce this risk among frequent drinkers. [Daigle LE, Johnson LM, Napper SL, Azimi AM. Protective behavioural strategies while drinking: do they protect against sexual victimisation and is this protection gendered?. Drug Alcohol Rev 2016;35:573-579].

Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke?

BACKGROUND AND PURPOSE: Platelet stromal-cell-derived factor-1 (SDF-1) plays a pivotal role in angiogenesis and the regeneration of ischaemic tissue through the regulation of haematopoietic progenitor cells and is upregulated at the sites of vascular injury and platelet activation. Thus, SDF-1 has recently been discussed as a predictor in ischaemic diseases such as acute myocardial infarction. However, no clinical data pertinent to the investigation of the platelet SDF-1 expression in patients with stroke are available. METHODS: We consecutively evaluated 196 patients who were admitted to the stroke unit with symptoms suspected for stroke. Surface expression of the platelet activation markers (P-selectin and GPIb) and the expression of platelet-bound SDF-1 were determined by two-colour whole blood flow cytometry. RESULTS: Patients with transient ischaemic attack (TIA) as well as with ischaemic stroke showed similar levels of SDF-1 expression on hospital admission compared with patients with non-ischaemic (NI) events and with 30 healthy controls (TIA (mean fluorescence intensity±SD): 31.5±18.2 vs. NI: 26.4±15.7; P=0.361; stroke: 28.7±19.8 vs. NI; P=0.943; control: 26.1±11.3; P>0.05 compared with all). Platelet SDF-1 expression showed a trend with the severity of stroke according to National Institute of Health Stroke Scale score (r=0.125; P=0.085), but significantly correlated with the peak levels of C-reactive protein (r=0.218; P=0.002) and with the levels of platelet activation (P-selectin: r=0.389; P=0.001). Multifactorial analysis of covariance revealed a significant influence on platelet SDF-1 expression by smoking (P=0.019). CONCLUSIONS: Platelet SDF-1 surface expression did not show any significant difference in patients with TIA and ischaemic stroke compared with patients with NI events. Thus, single biomarker evaluation of platelet SDF-1 surface expression is not helpful to predict ischaemic stroke.

Using magnetic resonance phase-contrast velocity mapping for diagnosing pelvic congestion syndrome.

OBJECTIVE: To evaluate phase-contrast velocity mapping (PCVM) as a diagnostic tool for pelvic congestion syndrome and comparing this approach with direct venography. METHOD: We prospectively include nine women with clinical suspicion of pelvic congestion syndrome during a six-month period. All patients underwent a magnetic resonance phase-contrast scan before a direct venography. We considered a case of pelvic congestion syndrome when the PCVM showed a retrograde or slow (less than 5 cm/second) flow in any gonadal vein. This criterion was compared with the standard diagnostic criterion observed from a direct venography. RESULTS: Using direct venography we found 14 abnormal veins and all of them were correctly identified by the PCVM. The other four veins were found to be normal by the direct venography. However, two of them (the same patient) were abnormal in the PCVM, even though this patient had the classical symptoms of pelvic congestion syndrome. CONCLUSION: PCVM is a useful tool for diagnosing pelvic contrast syndrome and can avoid invasive procedures such as direct venography.